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Why is sickle cell disease more common in African descent?

Why sickle cell Af

Sickle Cell Disease and Multiple Myeloma affects thousands of people throughout the world. Sickle Cell Disease is most common among those whose ancestors come from sub-Saharan Africa, Spanish-speaking regions in the Western Hemisphere, Saudi Arabia, and other Mediterranean countries while Multiple Myeloma is most common in Australia, North America, and Western Europe.

Sickle Cell Disease

Sickle Cell Disease also known as SCD, is a group of inherited red blood cell disorders. Healthy red blood cells are round and they move through small blood vessels to carry oxygen to all parts of the body. In someone who has SCD, the red blood cells become hard and sticky and look like a C-shaped farm tool called a “sickle”.

The sickle cells die early, which causes a constant shortage of red blood cells. Also, when they travel through small blood vessels, they get stuck and clog the blood flow. This can cause pain and other serious problems such as infection, acute chest syndrome and stroke.

In the United States, the exact number of people living with SCD is unknown. It is estimated by some that SCD affects approximately 100,000 Americans and SCD occurs among about 1 out of every 365 African American births and about 1 out of 16,300 Hispanic-American births. About 1 in 13 African American babies are born with sickle cell trait.

Sickle cell trait, also known as SCT, is an inherited blood disorder that affects approximately 8 percent of African Americans. Unlike SCD, in which patients have two genes that cause the production of abnormal hemoglobin, individuals with SCT carry out only one defective gene and typically live normal lives without health problems related to sickle cell. Rarely, extreme conditions such as severe dehydration and high-intensity physical activity can lead to serious health issues, including sudden death in individuals with sickle cell trait.

Related Post: What causes the sickle cell disease, How to prevent the sickle cell or treat the sickle cell?

So why are African Americans Affected More?

SCD and SCT impact African Americans at disproportionate rates. This is simply because they both are evolutionary traits that individuals develop in response to help protect them from malaria. Around 50% of the global population live in areas where malaria exists.

Unfortunately there is no cure for SCD, however research shows that a bone marrow transplant or stem cell transplant can help. If successful, a bone marrow transplant can cure sickle cell disease, however that comes with very significant risks if the patient is older.

Multiple Myeloma

Multiple Myeloma also known as MM,  is a cancer of plasma cells. Normal plasma cells are found in the bone marrow and are an important part of the immune system. The immune system is made up of several types of cells that work together to fight infections and other diseases.

Lymphocytes (lymph cells) are one of the main types of white blood cells in the immune system and include T cells and B cells. Lymphocytes are in many areas of the body, such as lymph nodes, the bone marrow, the intestines, and the bloodstream.

When B cells respond to an infection, they mature and change into plasma cells. Plasma cells make the antibodies that help the body attack and kill germs. Plasma cells are found mainly in the bone marrow. In general, when plasma cells become cancerous and grow out of control, that is what’s called MM.

The American Cancer Society estimates about 34,920 new cases will be diagnosed (19,320 in men and 15,600 in women) and about 12,410 deaths are expected to occur (6,840 in men and 5,570 in women).

MM only accounts for 2% of all cancers BUT is the most common blood cancer in African Americans. Furthermore, MM is the second most common in African Americans. African Americans have more than twice the incident rate of MM compared to white Americans. Also African Americans account for 20% of patients currently with Myeloma.

Related Post: What is Sickle Cell Trait?

So Why are African Americans Affected More?

It’s not completely clear why multiple myeloma is more common in African Americans, but researchers have found some contributing factors. A 2014 study of nearly 12,500 patients found that blacks are more likely than whites to have a condition that increases risk of MM. The condition is called monoclonal gammopathy of undetermined significance or MGUS.

MGUS occurs when your blood contains an abnormal protein called M protein. Almost all MM patients have MGUS. There’s also different types of MGUS that exist. Researchers also think that both environmental factors such as radiation and exposure are probably involved.

Just as a bone marrow transplant can help with sickle cell, a stem cell transplant can help with Multiple Myeloma. High-dose chemotherapy combined with a stem cell transplant is standard therapy for myeloma patients. It is not a cure, but has been shown to extend survival.

The National Bone Marrow Registry is so important for individuals with Sickle Cell Anemia and Multiple Myeloma. This stresses the importance of not only African Americans joining the registry but Asians, Hispanics, and Multi-Racial individuals.

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